[25] Unfortunately, none of the exercise studies in our analysis have examined glycaemic variability. There is recent evidence from patients with insulin treated type 2 diabetes that the time spent in hyperglycaemia is reduced in the 24 hrs following exercise (without an increase in hypoglycaemia), [26]. Conversely in type 1 diabetes, wide blood glucose variability has been reported around exercise in the few studies that have been conducted [27]. The gene discussed is INS; the disease is type 1 diabetes mellitus.