While Ft grown in Mueller-Hinton II broth (MHB) or on MH-based chocolate agar plates exhibits a capacity to elicit select pro-inflammatory cytokines (i.e., TNF, IL-1β, IL-6, IL-12, and IFN-γ) from a variety of cell-types within 24 h of in vitro infection, such TH1-oriented molecules are absent during the first 72 h of in vivo infection [5], [14], [15]. The gene discussed is TNF; the disease is infection.