These stressors include diverse events such as chronic traumatic encephalopathy injury [1], Alzheimer's disease (AD) [2], HIV encephalitis (HIVE) [3], [4], and frontotemporal dementia (FTD) [5] and can manifest, in part, as accumulation of hyperphosphorylated Tau (hp-Tau). Here, MAPT is linked to Alzheimer disease.