Immunoprecipitation of tissue lysate from an AD patient's brain supported the interaction of PINCH with hpTau as shown by two immunoreactive bands at approximately 55–60 kDa, 42 kDa (Figure 6H, arrows) and a weaker band at 82 kDa (Figure 5H, arrowhead). The gene discussed is LIMS1; the disease is Alzheimer disease.