A plausible basis for association between FOXP2 variants and obesity is through its involvement in neurodevelopment [28], whose importance in feeding behaviour is well-established [29]; alternatively, an obesity-related phenotype might be independent of effects on FOXP2, and result instead from deletion of a putative NF-κB binding site. The gene discussed is NFKB1; the disease is obesity due to melanocortin 4 receptor deficiency.