However, of the 10 predicted deletions at the locus on chromosome 7q31.1 that were identified in our population cohort, 5 extend substantially beyond the GSV region previously identified as obesity-associated (Figure 3), which spans 1–3 small exons that (depending on the splice variant) encode either part of the 5′-untranslated region of the FOXP2 mRNA or a small part of the N-terminal of the protein. The gene discussed is FOXP2; the disease is obesity due to melanocortin 4 receptor deficiency.