Results of multivariate analyses, adjusted for the tumor characteristics, ethnicity, and the four VDR polymorphic variants, confirm the independent predictor value of VDR-FokI in DFS as shown in Table 6. The relative risk of tumor recurrence or metastases was decreased by 43% in patients who had the polymorphic VDR-FokI alleles, Ff or ff, compared to subjects who had VDR-FokI FF genotype (Table 6). Here, VDR is linked to neoplasm.