NR1I2 and inflammatory bowel disease: Analysis of the polar extracts afforded anti-inflammatory peptides such as the large library of perthamide C derivatives [3]–[6] and solomonamides A–B, [7] and anti-inflammatory sulfated sterols, solomonsterols A and B [8], potent agonists of the human nuclear receptor and xenobiotic sensor, pregnane-X-receptor (PXR) and new leads in the treatment of immune-driven inflammatory bowel diseases [9].