The TH2 associated cytokine IL-4 was found to be produced by a significantly higher proportion of Il27ra−/− CD4+ T cells in the TDLN, and numbers of splenic IL-10 producing cells were significantly reduced, when MCA-induced fibrosarcoma bearing mice were analyzed (Fig. 3 F,G), while IL-17 producing CD4+ T cells remained unchanged (Fig 3H). Here, CD4 is linked to fibrosarcoma.