Furthermore, as shown by way of immunoblot analysis, we detected an increase of both the total and nuclear β-catenin protein after restoration of CDH17 in AGS and MKN-45, when compared with the shCDH17 (Fig. 5C).Together, these results indicate that CDH17 knockdown results in downregulation of the Wnt/β-catenin pathway in gastric cancer cells. Here, CDH17 is linked to gastric cancer.