Proteomics analysis of serum samples from 65 NAFLD patients (with varying biopsy proven stages of disease) showed that several apolipoproteins have >14% differences (P < 0.05) in their serum concentration as compared with 16 obese controls, including apoA-II, apoA-IV, apoB, apoC-I, apoC-III and apoL-I[116]. The gene discussed is APOB; the disease is metabolic dysfunction-associated steatotic liver disease.