Under insulin resistance state, all of the three major sources of hepatic TAG increased, namely, the albumin bound free fatty acid (FFA) from lipolysis of adipose tissue, the fatty acids metabolized from circulating chylomicrons and VLDL-derived lipoproteins via lipoprotein lipase (LPL), and fatty acids from de novo lipogenesis[29]. The gene discussed is LPL; the disease is Insulin resistance.