It was reported that some probiotics have the ability to prevent and alleviate allergic disease by inducing a Th1 bias.[25],[26] However, in our study, the oral administration of LFK had no effect on systemic IL-4, IFN-γ, and OVA-specific IgE levels, as evidenced by the levels in both the sera and splenocyte culture supernatants. This evidence concerns the gene IGHE and allergic disease.