The effects of renal TSP-1 gene silencing on the excretion of urinary protein of Thy-1 nephritis rats were detected, and the results showed that shTSP-1 reduced the content of urinary protein (mg/24 h) of Thy-1 nephritis rats on d 7 after induction of nephritis compared with shCTR treatment (Fig. 8), implicating that inhibition of the renal TSP-1 gene could not only suppress proliferative pathologic changes, but also ameliorates the renal function of Thy-1 nephritis rats. The gene discussed is THBS1; the disease is nephritis.