In particular, a significant association of ischemic stroke with ALOX5AP polymorphisms was found in Scottish[9], German[16], Chinese[14],[17], white American[18], Japanese[19], British[20], Spanish, and Portuguese[21] populations, whereas no evidence of a significant association was reported in different American[22]–[24], Swedish[25],[26], and Italian[27] cohorts. This evidence concerns the gene ALOX5AP and ischemic stroke.