After adjustment of other risk factors such as age, smoking, hypertension, diabetes, TG, CHO, LDL, HDL, apoA, apoB and Lp(a) the AG genotype of the LAA group and the AG and AA+AG genotypes of the SAO group were still significantly associated with stroke, while there was not significant association between the AA+AG genotype and stroke in the LAA group after adjustment of other risk factors mentioned above, the AG and AA+AG genotypes of the ICH group were not significantly associated with stroke even after adjustment other risk factors mentioned as above. The gene discussed is APOB; the disease is southeast Asian ovalocytosis.