Previous studies have demonstrated that ROS contributes to vascular endothelial growth factor (VEGF) or platelet-derived growth factor (PDGF)- induced activation of the PI3K/Akt, P70S6K1 and hypoxia-inducible factor 1α (HIF-1α) in various types of cells[14],[15], and the activation of Rac1/ROS is critical in regulating cell motility, adhesion and tumor angiogenesis[16]–[19]. The gene discussed is VEGFA; the disease is neoplasm.