In a recent case-control study, we identified one SNP rs11134527 located in the pri-miR-218 sequence and one SNP rs2566 in the 3′ UTR of LAMB3 and found that the pri-miR-218 rs11134527 variant homozygote GG was associated with a decreased risk of cervical cancer (OR=0.72, 95%CI=0.52-0.99), while the LAMB3 rs2566 variant CT/TT genotypes were associated with a significantly increased risk of cervical cancer (OR=1.57, 95%CI=1.25-1.96), although the functional relevance of these two SNPs have not well characterized[74]. The gene discussed is LAMB3; the disease is cervical carcinoma.