Through analysis of rs17817276 in the PPAR-γ gene, we found that there were more pronounced reductions in T2DM risks in male and old individuals carrying the rs17817276GG genotype [OR(95%CI)=0.36(0.16-0.80), 0.48(0.26-0.91)]. This evidence concerns the gene PPARG and type 2 diabetes mellitus.