PTGS2 and lipoid nephrosis: It has been shown that IL-13 potently inhibits the expression of the inducible isoform of nitric oxide synthase (iNOS) and cyclooxygenase-2 and prostaglandin E2 production by mesangial cells[6],[15], and inhibits vascular permeability factor release by peripheral blood mouonuclear cells (PBMCs) from patients with lipoid nephrosis[16].