Preferential accumulation in hippocampus, thalamus, parietal cortex, and striatum, inducing lipid peroxidation Increased expression of SOD and CAT to counteract the oxidative stress and ↑lipid peroxidation in hippocampus and cerebellumN-acetyl-cysteine improve TAC of brain decreasing lipid peroxidation damage by lead↓Nitric oxide causing hypertension and neuronal mitochondiral impairment↑Lipid peroxidation and ↓ GST, CAT and SOD in bone of rats. Here, SOD1 is linked to hypertensive disorder.