In addition, the negative correlations found between enzymatic antioxidant activity (GPx and SOD) and circulating oxidative-glycation products (AOPP and pentosidine) in both DNR and DR patients in this study (Tables 2 and 3) confirmed the inverse relationship between the antioxidant status and hyperglycemia-dependent cellular changes in patients with type 2 DM. The gene discussed is SOD1; the disease is Hyperglycemia.