KLK3 and Familial prostate cancer: Other inclusion criteria required men to be healthy, have total PSA ≤ 4.0 ng/mL, have a DRE not suspicious for cancer, have no previous prostate cancer or high grade prostate intraepithelial neoplasia, have normal blood pressure, not be currently taking anticoagulation therapy, and be willing to stop taking off-study supplements [61].