CEACAM5 and lymphopenia: As shown in Table 2, cox regression model showed chemotherapy-associated lymphopenia <0.66 × 109/L (HR, 3.521; 95% CI = 1.703-7.282), pretreatment CEA ≥10 ng ml-1 (HR, 1.827; 95% CI = 1.040-3.211), stage III (HR, 2.723; 95% CI = 1.549-4.786) were independent prognostic factors for DFS, and 99 (40.7%) cases had all of those negative prognostic factors.