TLR4 and prostate adenocarcinoma: Moreover, it has been reported that rat prostate adenocarcinoma derived MAT-LU cells constitutively express TLR4 and respond to the TLR4 ligand LPS through the activation of ERK1/2 and NF-kB, up-regulating numerous chemokines such as MCP1, MIP1a, IP10, RANTES and IL-8 39.