TLR3 and neoplasm: The direct apoptotic effect of TLR3 stimulation was only partially confirmed in a subsequent study in which the authors evaluated the effect of poly (I:C) on TRAMP-C2 murine PCa cells transplanted in syngeneic mice, showing that the suppression of tumour growth induced by poly(I: C) was dependent on T-lymphocyte and NK cells recruitment in the tumour microenvironment.