Objectives of the current study include: 1) Determination of the distribution of IL28B rs12979860 and rs8099917 genotypes in Iranian patients with chronic hepatitis C, 2) Determination of the distribution of IL28B rs12979860 and rs8099917 genotypes in Iranian healthy individuals, 3) Comparison of the distribution of IL28B rs12979860 and rs8099917 genotypes between Iranian healthy individuals and patients with chronic hepatitis C. This evidence concerns the gene IFNL3 and chronic hepatitis C virus infection.