The impact of ghrelin on anxiety behaviors remains controversial: studies show an anxiolytic effect under caloric restriction or after subcutaneous ghrelin injection (Lutter et al., 2008) while anxiogenic effects are observed in others (acute) studies with intracerebroventricular or intraperitoneal ghrelin injection (Asakawa et al., 2001; see review Chuang and Zigman, 2010). Here, GHRL is linked to Anxiety.