We have developed a humanized anti-IGF-1R antibody, hR1, which binds to IGF-1R without blocking binding of IGF-1 or IGF-2 to the receptor, yet effectively causes receptor down-regulation, and inhibits cell proliferation, colony formation, and cell invasion in a variety of cancer types, including breast, prostate, cervical, pancreatic, and rhabdomyosarcoma [16]. The gene discussed is IGF1R; the disease is cancer.