Indeed, VNAR therapy showed to be more effective than F(ab’)2 to suppress IL-6 mRNA expression at 24 h (1.33 versus 34.27; p < 0.05) and 48 h (5.69 versus 24.20 p < 0.05) after induction of endotoxemia. This evidence concerns the gene IL6 and serum lipopolysaccharide activity.