Endotoxemic shock was also associated with an early raise of IL-10 (Figure 2, panel B) in untreated (598 ± 116 pg/mL; p < 0.01 vs. animals with no endotoxemia), treated with anti-TNF F(ab’)2 (854 ± 169 pg/mL; p < 0.001) and with VNAR groups (418 ± 119 pg/mL). Here, TNF is linked to serum lipopolysaccharide activity.