Multivariate Cox regression analysis demonstrated that baseline eGFR or CKD status were independent predictive factors of 28-day mortality after adjustments for multiple confounders (age, gender, history of diabetes, hypertension, heart failure, peripheral artery disease, coronary artery disease, COPD, statins, creatinine and Hb on admission) (Table 4). This evidence concerns the gene GSTM1 and heart failure.