The former was represented by JUNB, BCL2, MLLT10, FES, FOS and MCL1, and the latter was represented by RUNX1, CEBPA and STAT3. Similarly, the most significant KEGG pathways revealed in this gene set were represented by those involved in acute myeloid leukemia, including SPI1, RARA, KRAS and so on (Figure 4H and Additional file 8: Figure S5). This evidence concerns the gene RARA and acute myeloid leukemia.