Immunohistochemical analysis of the vessel associated markers murine PECAM-1/CD31 and laminin showed an obvious shift from initial tumor vascularization (HUH-wt) (Figure 3A), as it is typical for HUH7 xenografts, to a tumor tissue with a decreased murine vessel density (HUH-REISO) (Figure 3B) at the therapy endpoint. This evidence concerns the gene PECAM1 and neoplasm.