However, multivariate Cox regression demonstrated that the dichotimised 3-panel score was not a significant predictor of either BCSS (HR = 6.38; 95% CI = 0.79-51.26, p = 0.082) or RFS (HR = 1.46; 95% CI = 0.66-3.19, p = 0.348), when adjusted for other well-established variables, namely tumour grade, tumour size, age at diagnosis, ER, PR, Her2, Ki67 and nodal status. The gene discussed is ESR1; the disease is neoplasm.