We have utilised a large collection of UK Caucasian JIA samples and controls to determine SNP associations with the autoinflammatory disease related loci MVK, TNFRSF1A, NLRP1, IL1 ligand and IL1 receptor. Data collected from a US genome wide association study of JIA was available for validation of any significant findings. The gene discussed is IL1B; the disease is juvenile idiopathic arthritis.