SCNN1A and juvenile idiopathic arthritis: One SNP, rs2228576, at the 3’ end of the TNFRSF1A, but which actually lies within the adjacent gene sodium channel, non-voltage-gated 1 alpha (SCNN1A), was associated with JIA (ptrend=0.009 OR 0.87 95% CI 0.78-0.97) (Table 1).