Unlike IL-1β and IL-12 which were not detectable (data not shown), IL-8 (Figure 1a) and to a lesser extend IL-10 increased after each OM-174 injection within same range, whereas peaks of TNF-α and IL-6 concentrations decreased from the first to the last injection of OM-174, suggesting tolerance (Figures 1b and 1c). Here, TNF is linked to ocular melanoma.