As OM-174 has been shown, in mice, to induce TNF-α production via TLR4 receptors, a family of receptors which recognized pathogen-associated microbial structure and are involved in innate immune cell activation and antitumor immune response inducing tumor cell death [37], we search for possible mutations that may explain inter patient variability in terms of biological and clinical activities. The gene discussed is TNF; the disease is neoplasm.