For example, in the case of renin vaccine, the autoimmune nephritis was induced by the observation of immune complex depositions which can be characterized by glomerulosclerosis, mesangial hypercellularity, leucocyte accumulation, endocapilarry proliferation or immune complex deposition.[31], [32] As shown in Figure 6A, no pathological changes were observed in control or immunized group, no T-cell or macrophage infiltrations were observed in kidney or heart with coronary artery. This evidence concerns the gene REN and glomerulosclerosis.