Furthermore, increased production of IL-6, IL-1β, IFN-γ and TNF-α, as well as signs of an acute phase response, i.e. increased production of positive acute phase proteins (APPs) and decreased production of negative APPs, are associated with depression [13], [14], [17], [18], [19], [20], [21]. The gene discussed is IFNG; the disease is depressive symptom measurement.