In conclusion, CCNE1, CDC25A, and CDK4 together with CDK6 seem to be the most important factors among 8 target genes because of their frequent tumor-specific up-regulation in HCC together with significant inverse correlation with miR-195 and miR-497 expression in primary HCCs relevant to cell cycle progression regulated by miR-195 and miR-497 in HCCs. The gene discussed is CDK4; the disease is neoplasm.