Moreover, the inhibition of the class I and II histone deacetylase (HDAC) families with Tricostatin A (TSA) did not induce restoration of miR-195 nor miR-497 in most of cell lines, suggesting that these HDACs do not strongly contribute to the decreased expression of those miRNAs in HCC cells (Fig. S3C). The gene discussed is HDAC9; the disease is hepatocellular carcinoma.