SH2B1 and obesity due to melanocortin 4 receptor deficiency: The most commonly cited genes related to obesity are the fat mass and obesity associated gene (FTO) [12], [13], mitochondrial carrier homolog 2 (MTCH2) [13], transmembrane protein 18 (TMEM18), glucosamine-6-phosphate deaminase 2 (GNPDA2), brain derived neurotrophic factor (BDNF), neuronal growth regulator 1(NEGR1), SH2B adaptor protein 1(SH2B1), ETS transcription factor 5 (ETV5), and potassium channel tetramerisation domain (KCTD15) [14].