In animal studies, this insulin resistance is explained by impairment of insulin signaling through the phosphoinositide 3-kinase pathway due to reduced intrinsic tyrosine kinase [6] or inhibition of Akt and protein kinase Cζ phosphorylation by increased expression of the inhibitors Pten (phosphatase and tensin homologue deleted on chromosome 10) and Trb3 (tribbles 3) [8], [9], [10]. This evidence concerns the gene INS and Insulin resistance.