The Jun-Fos Activator Protein-1 (AP-1), is a helical heterodimer and oncogenic transcriptional regulator implicated in a range of diseases that includes cancer [36], [37], [38], bone disease (e.g. osteoporosis) and inflammatory diseases such as rheumatoid arthritis and psoriasis [39], [40], [41]. This evidence concerns the gene FOS and cancer.