Concerning the prognostic value of SOX2 expression in tumors, contradictory results have been reported in different tumor entities, depending on their localization and histology: while some studies suggest that increased SOX2 expression is associated with a prolonged overall survival in patients suffering from lung SCCs [13], [17], [26] others refer to a high SOX2 expression as a marker of poor prognosis in esophageal SCC [27], oral SCC [28] or lung AD [18]. The gene discussed is SOX2; the disease is esophageal squamous cell carcinoma.