One SNP, rs9348512 at 6p24 not known to be associated with breast cancer, had a combined P-value of association of 3.9×10−8 amongst all BRCA2 samples (Table 2), with strong evidence of replication in the set of BRCA2 samples that were not used in the discovery stage (P = 5.2×10−5). Here, BRCA2 is linked to breast cancer.