Taking into account all loci associated with breast cancer risk in BRCA2 mutation carriers from the current analysis, including the 6p24 locus, the 5% of the BRCA2 mutation carriers at lowest risk were predicted to have breast cancer risks by age 80 in the range of 21–47% compared to 83–100% for the 5% of mutation carriers at highest risk on the basis of the combined SNP profile distribution. The gene discussed is BRCA2; the disease is breast cancer.