In a rapid replication stage wherein 85 discovery stage SNPs with the smallest P-values were genotyped in 2,486 additional BRCA2 mutation carriers, only published loci associated with breast cancer risk in the general population, including FGFR2 (10q26; rs2981575; P = 1.2×10−8), were associated with breast cancer risk at the genome-wide significance level among BRCA2 mutation carriers. This evidence concerns the gene BRCA2 and breast cancer.