Previously reported BRCA2-modifying alleles for breast cancer, including those in FGFR2, TOX3, MAP3K1, LSP1, 2q35, SLC4A7, 5p12, 1p11.2, ZNF365, and 19p13.1 (ER-negative only) [18], [32], [33], are also associated with breast cancer risk in the general population and/or BRCA1 mutation carriers. The gene discussed is TOX3; the disease is breast carcinoma.