GCG and Stroke: The mechanism is speculative; but as the maximum activity of hexokinase appears to be increased, by a GLP-1 mediated activation of the AMP-activated protein kinase (AMPK) is suggested by evidence from an animal stroke model (Hou et al., 2012), with possible increase of metabolism and GLUT1 activity (Ronnett et al., 2009; Cura and Carruthers, 2012).