It is uncertain how GLP-1 lowers the Ctissue during hyperglycemia, but we reason that the most likely effect would be on the CMRglc by change of the maximum phosphorylation velocity, e.g., by influencing the activity of hexokinase to a greater extent than the transporter density in the endothelial membranes. The gene discussed is GLP1R; the disease is Hyperglycemia.