The trend toward decline of the lumped constant with GLP-1 in hypoglycemia is a further indication of the potentially protective effect of the peptide, because the rise of the lumped constant in hypoglycemia is the obligatory result of the effect of low glucose on the competition between the tracer FDG and native glucose (Gjedde et al., 1985). The gene discussed is GLP1R; the disease is Hypoglycemia.