They further showed that TARBP2 depletion in Ewing Sarcoma cell lines results in downregulation of a group of miRs depleted in CD133+ cells and enhanced tumor xenograft growth, while augmentation of TARBP2 activity, via treatment with the fluoroquinolone-class antibiotic enoxacin, results in upregulation of these miRs and impaired tumor xenograft growth. Here, TARBP2 is linked to sarcoma.