Since transcription and processing represent important mechanisms of control of miR levels in the cell (Davis and Hata, 2009; Kim et al., 2009; Winter et al., 2009), it was reasonable to postulate that EWS/Ets fusions affect the expression of miRs in Ewing Sarcoma, and that consequent alterations in miR levels contribute to the execution of the EWS/Ets-driven oncogenic program. This evidence concerns the gene EWSR1 and Ewing sarcoma.