Given the differences among studies using a similar experimental approach (EWS/Fli1 depletion), it is equally striking how similar the profiles are between the more divergent approaches taken by McKinsey et al. (depletion of EWS/Fli1) and De Vito et al. (2011a) (profiling of Ewing Sarcoma cell lines versus MSCs). This evidence concerns the gene EWSR1 and Ewing sarcoma.