ELP3 and nervous system disorder: With regards to non-chromatin associated cellular processes, the acetyltransferase Elp3 known to acetylate microtubules has been shown to be involved in the regulation of synaptic bouton expansion during neurogenesis (Singh et al., 2010) and recent studies suggest that regulation of microtubule acetylation by the ELP3 might be commonly affected in neurological diseases making it a potential target for acetylation modulator based therapies [reviewed in Nguyen et al. (2010)].