DNMT1 and Parkinson disease: In fact, “synucleopathies” such as Parkinson's disease and dementia with Lewy bodies are associated with dysregulation of DNA methylation at the promoters of several disease-associated genes, an effect primarily mediated by cytoplasmic sequestration of DNA methyltransferase 1(Dnmt1) by α-synuclein that results in a decrease in nuclear Dnmt1 (Desplats et al., 2011).