The HAT, Tip60 has been reported to interact with ataxin 1 protein in Spinocerebellar ataxia 1 (SCA1) mouse model and contribute to cerebellar degeneration associated with SCA1, a neurodegenerative disease caused by polyglutamine tract expansion in the ataxin-1 protein (Gehrking et al., 2011). Here, KAT5 is linked to spinocerebellar ataxia type 1.