CREBBP and Parkinson disease: The initial link between PD and deregulation of histone acetylation came from observations that the PD linked presynaptic protein, α-Synuclein (α-Syn), binds histones and as a result inactivates HATs like CBP, p300 and PCAF, causing apoptosis in human neuroblastoma cells (Kontopoulos et al., 2006).