CREB1 and Alzheimer disease: For example, the pathological sequestration of transcription factors vital for neuronal health, such as the cAMP response element-binding protein CREB and its binding partner CBP, a histone acetyltransferase (HAT), has been linked to the beta amyloid plaques seen in the brains of individuals with Alzheimer's disease (AD) (Tong et al., 2001; Vitolo et al., 2002; Caccamo et al., 2010).