As such, rifampicin is a classic ligand for PXR and not only is effectively used to treat pruritus but also improves liver function tests in PBC, compatible with a direct anti-cholestatic effect.115–117 In the otherwise healthy gallstone patients, rifampicin enhanced BA detoxification as well as bilirubin conjugation and excretion through induction of CYP3A4, UGT1A1, and MRP2, thereby decreasing bilirubin and deoxycholic acid concentrations in serum as well as lithocholic (LCA) and deoxycholic acid concentrations in bile.118. Here, NR1I2 is linked to primary biliary cholangitis.