Other hypolipidemic drugs, such as inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (statins), are indirect activators of PPAR, also have pleiotropic anti-inflammatory effects,203 and stimulate phospholipid secretion by induction of Mdr2.204,205 Statins have also been tested in the treatment of PBC. Here, ABCB4 is linked to primary biliary cholangitis.