Phenobarbital was also given to patients long before the identification of CAR as its molecular target.115,121,122 Notably, 6,7-dimethylesculetin, a compound present in Yin Chin used in Asia to prevent and treat neonatal jaundice, accelerates bilirubin clearance by activation of CAR.123. This evidence concerns the gene NR1I3 and neonatal jaundice.