CHMP2B and amyotrophic lateral sclerosis: Charged multivesicular body protein 2B (CHMP2B), a component of the endosomal sorting complex, causes vacuolisation, lysosomal mis-localisation and impaired autophagy in cultured cells and has been associated with frontotemporal dementia (FTD; FTD3) and ALS (ALS17) (Parkinson et al. 2006; Cox et al. 2010).