TARDBP and amyotrophic lateral sclerosis: ALS-associated mutations in TDP-43 and FUS lead to loss of nuclear localization, re-localization to the cytoplasm, and inclusion in cytoplasmic stress granules—a rapid, reversible cellular response to stress, controlling RNA metabolism (Liu-Yesucevitz et al. 2010; Ito et al. 2011; Dormann et al. 2010).