CD4 and amyotrophic lateral sclerosis: Proinflammatory cytokines have been reported in the CSF of ALS patients (Kuhle et al. 2009) and evidence from mutant SOD1 transgenic mice lacking CD4, which develop an aggravated neurodegeneration (Beers et al. 2008), indicate that the inflammatory reactions have an impact on the ALS neurodegeneration.