PFN1 and amyotrophic lateral sclerosis type 18: Recently, mutations in Profilin 1 (PFN1), which is crucial for the conversion of g-actin to filamentous f-actin, have been linked to fALS (ALS18) with ubiquitinated insoluble inclusions including TDP-43 and mutant PFN1 (Wu et al. 2012).