In conclusion, our study demonstrates that cardiac amyloidosis patients with immunoglobulin light chain in the heart (AL‐CMP), despite less LVH and relatively preserved LVEF, have higher levels of MMP‐2, TIMP‐1, and MMP‐2/TIMP‐2, as well as increased BNP and TnI compared with patients with transthyretin deposition in the heart (TTR‐CMP). Here, MMP2 is linked to cardiac amyloidosis.