ESR1 and cystic fibrosis: The most interesting transcription factor identified in the context of our data was ESR1 (estrogen receptor 1), given a recent study of sex related differences in modulation of CF symptoms by estrogen [40], and the gene for ESR1, while not within the cut-offs of our working list (Additional file 1) was nevertheless 1.84-Fold up-regulated in CF (FDR = 0.026, p = 0.0004: see extended list in Additional file 4).