FOXP3 and breast carcinoma: Increased numbers of Tregs have been associated with a worse breast cancer prognosis [31-33], For example, Bates et al. reported that high numbers of FoxP3-positive Tregs were identified in patients with ductal carcinoma in situ at increased risk of relapse, and in patients with invasive breast tumors with both shorter relapse-free and overall survival [30].