In the present study, we therefore analyzed the expression patterns of ACY1, SQSTM1, and GPC3 among low-grade DN (LGDN), HGDN, WDHCC and moderately differentiated HCC (MDHCC), and determined the accuracies of different panels of markers using ACY1, SQSTM1, and GPC3. Here, SQSTM1 is linked to hepatocellular carcinoma.