TYR and melanoma: Variations in one of the genes causing oculo-albinism syndrome (OCA2) were associated with melanoma in other studies [24,25], Agouti signaling protein (ASIP) was found to modify melanoma risk in the presence of MC1R variants [12], and the Tyrosinase gene (TYR) has variants which code for skin color and are implicated in tanning response [26,27].